The snapping of Thanos' fingers was felt in all corners of the universe, including that of a small diner in New York City. Jessica Drew sat eating with her family celebrating her 17th birthday when the young girl ceased to exist in their world. With life restored 5 years later thanks to the Avengers, Jessica Drew returns home with the idea of resuming the life she lived prior to "The Blip," but the bite from a radioactive spider has different plans for the young girl. She must now navigate life with her newfound abilities and decide whether to sit and watch as her hometown falls into the hands of a gang, or save the city she loves.