Teresa lives in the barrio of Culiacán in Sinaloa, Mexico. She falls in love with a member of a drug cartel, and tries to rise above her life's impoverished condition. After she is told her boyfriend has been murdered, she is forced to flee. She crosses the border to the United States where she ends up in the criminal organization of the wife of the cartel boss who is after her. Teresa has a different vision of the drug distribution business and due to her charisma attracts associates and ends up starting her own drug distributing organization. Teresa becomes very successful, which presents her with more problems, makes her endure sacrifices and attracts the attention of covert government forces.

Two women share a supernatural destiny that ties them together after being killed. Luisa a wealthy business woman dies at the hand of her husband and niece. But by way of a Talisman, Luisa’s soul which does not accept defeat occupies body of Dolores a young lady that dies at the hands of robbers . Now in dolores’s body , Luisa will do the impossible to defend her children and seek justice while Dolores’s soul wanders this world . It is love that can only save Dolores, but Luisa will resist this until her mission has been completed. She wants to take revenge.